Introducing the ACCQPrep SFC. Green Preparative SFC: Chiral or Achiral Separations in a Single, Compact S​​olution

Teledyne ISCO’s ACCQPrep SFC expands upon the success of the ACCQPrep line to now include Supercritical Fluid Chromatography (SFC) applications. Combining the time and solvent saved by SFC, and being designed with ease of purification in mind, the user-friendly system greatly simplifies prep run setups as compared to other systems. The standalone platform is controlled by integrated software with a 15-inch interface, eliminating the need for a separate PC. Combined with other space-saving innovations, this has produced the smallest footprint SFC on the market today.

The robust pumping system at the core of the ACCQPrep SFC is paired with an integrated mass-flow controller for accurate CO2 delivery. Samples are collected with greater than 95% recovery on the open-bed SFC (with optional AutoSampler) at all flow rates up to 200 mL/min. The patented Gas-Liquid Separator minimizes carryover to allow for greater flexibility between applications. ACCQPrep SFC allows cosolvent compositions up to 70%, enabling elution of more polar compounds, as compared to competing systems.

The ACCQPrep® SFC is a compact system that simplifies method complexity and ensures successful separations for users of all experience levels. As the only system to enable both bulk collection from stacked injections, and multi-sample, open-access with an optional SFC AutoSampler (2x2 or 4x2), the ACCQPrep SFC offers versatility without limitations; all in the smallest Prep SFC footprint on the market.

Stacked injections increase throughput by performing additional injections, while compounds from previous injections elute. The PeakTrak® software’s Stacked Injection Wizard intelligently determines cycle time and fraction collection settings, automatically suggests “time windows” for collection of desired peaks, and injection simulation assists the user in visualizing the effect of method modifications.

Because the dynamic nature of supercritical CO2 requires accurate flow control and back pressure regulation, the ACCQPrep SFC has a robust CO2 pumping system paired with an advanced mass-flow controller and automated backpressure regulation. Prior to fraction and waste collection, the patented Gas-Liquid Separator (GLS) minimizes carryover, resists clogging, and permits high cosolvent flow. Finally, a standard fractionation valve sorts collection into up to eight vessels or output to 2x2 or 4x2 SFC AutoSampler for full open-bed fraction collection with >95% recovery up to 200 mL/min.