Fast and easy method development for large scale processes

Before implementing large scale processes, the most straightforward approach is to develop and refine separation methods on a laboratory scale. Only then, risks and resource consumption can be kept on a bare-minimum. Also, it allows fast process modifications.

Self-packed glass columns are “the” lab tool for quick screenings due to two reasons:

• any stationary phase available already in the lab can be chosen and
• the packing is fast so that results are quickly obtained.

ECO^PLUS columns as the perfect tool in method development

The approach has been successfully used in a recent study by Stefan Schmidt et al. They developed a brand-new method to purify mAb in large-scale production. Their approach was based on self-packed ECO^PLUS glass columns.

The advantages are:

• Low sample, resin and solvent consumption
• High reproducibility
• Easy column packing
• Full biocompatibility for BioLC applications

You want to read more? Check out our Technical Note.