Endometrial hyperplasia and carcinoma analysed with liquid chromatography

Liquid chromatography has been used to study biomarkers for endometrial hyperplasia and carcinomas.

Published in the Journal of Hematology and Oncology, the study highlights that these types of gynaecological malignancy are the most common - and current diagnosis involves invasive procedures.

The research team therefore attempted to discover proteins that could be used as biomarkers to help diagnose the issues without the use of invasive techniques.

Samples from women with different types of endometrial hyperplasia and carcinoma, as well as healthy subjects, were taken and analysed using liquid chromatography and mass spectrometry.

Following the tests, some seven proteins were discovered to present differently in cases of atypical endometrial hyperplasia.

"The differentially expressed proteins we discovered in this study may serve as biomarkers in the diagnosis and follow-up of endometrial hyperplasia and endometrial carcinoma," the team concludes.

An open-access online resource, the Journal of Hematology and Oncology publishes research following peer reviews.