Mass spectrometry: Anti-malarial properties proven in new compound

Scientists have identified a new compound present in ethanolic fractions of Caesalpinia pluviosa, which could explain the plant's anti-malarial properties.

Originating in Brazil, the substance was tested by scientists hoping to find more solutions for malaria treatments and the results were published in the Malaria Journal.

Increasing drug resistance means that current solutions are rendered less effective, the researchers note, adding that traditional remedies are therefore being looked to for alternative therapies.

The stem bark was purified into seven fractions using a number of solvents.

Mass spectrometry, among other methods, was then employed to assess the effectiveness of each fraction in vitro and in vivo.

Against 3D7 and S20 strains of the disease, two of the fractions - 100 per cent ethanolic (F4) and 50 per cent methanolic - were found to possess anti-malarial qualities.

"Mass spectrometry analyses suggest that a new compound, most likely an isomer of quercetin, is responsible for the anti-malarial activity of the F4," the ten-strong team concludes.

An open-access online publication, Malaria Journal releases articles following peer review.