Electrophoretic Separations
Saliva used to identify disease biomarkers
Nov 03 2011
Posted by Neil Clark
Scientists have used quantitative analysis processes to clarify the clinical and functional changes of the salivary glands driven by autoimmune and lymphoproliferative processes.
In a study published by the Journal of Translational Medicine, scientists from the Department of Internal Medicine at the University of Pisa, noted that human proteomic has represented a promising tool to promote the communication between basic and clinical science for several years.
As part of the study, a proteomic approach was used to analyse the whole saliva of a patient with primary Sjogren's Syndrome (pSS) and non-Hodgkin's-MALT type parotid lymphoma before, during and after a standard treatment with cyclophosphamide (CTX) and rituximab (RTX).
The results obtained from the saliva study indicated that there were a number of qualitative and quantitative modifications.
To conclude, the report stated that clinical and functional changes in saliva are driven by autoimmune and lymphoproliferative processes, "shedding new light on the potential usefulness of salivary proteomic analysis in the identification of prognostic and therapeutic biomarkers".
Digital Edition
Chromatography Today - Buyers' Guide 2022
October 2023
In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...
View all digital editions
Events
Nov 18 2024 Shanghai, China
Nov 18 2024 Plainsboro, NJ, USA
Nov 20 2024 Karachi, Pakistan
Jan 20 2025 Amsterdam, Netherlands
Feb 03 2025 Dubai, UAE