Quantitative analysis used in apolipoprotein A1/C3/A5 haplotypes study

Scientists have used quantitative analysis methods to investigate the association between the apolipoprotein (Apo) A1/C3/A4/A5 gene polymorphisms and their haplotypes.

In a study published by Lipids in Health and Disease and undertaken by researchers in the US and China, the team sought to learn more about the association of single nucleotide polymorphisms (SNPs) in the apolipoprotein (Apo) A1/C3/A4/A5 gene cluster and serum lipid profiles, as the current known relationship is inconsistent.

The scientists used quantitative analysis processes to genotype the ApoA1/C3/A5 gene polymorphisms of some 1,030 unrelated subjects, comprising 492 males and 538 females, aged 15 to 89, from the Chinese population.

It found that high-density lipoprotein cholesterol (HDL-C) and ApoA1 was lower in men than women, while the allelic and genotypic frequencies of the SNPs showed no gender differences.

"Several common SNPs and their haplotypes in the ApoA1/C3/A5 gene cluster are closely associated with modifications of serum lipid parameters in the general Chinese population," the report concluded.