• Quantitative analysis of diabetic patients conducted with CE-MS
    CE-MS used in quantitative analysis of diabetes interventions

Electrophoretic Separations

Quantitative analysis of diabetic patients conducted with CE-MS

Nov 03 2010

High-resolution capillary electrophoresis with mass spectrometry (CE-MS) has allowed for quantitative analysis to be conducted of Type 2 diabetes patients undergoing renoprotective therapy.

Microalbuminuria is a condition that occurs when leakages into the urine take place of small amounts of albumin.

In Type 2 diabetic patients, renoprotective treatment is used to prevent the condition progressing to macroalbuminuria - where the amount excreted exceeds 300 mg in a day.

Published in BMC Nephrology, the quantitative analysis of treatment using Irbesartan daily for a two-year period indicates that turnover of collagen and associated fibrosis reduction could be among the major benefits of the therapy.

The findings show a significant change in the urinary proteome following two years of daily 300 mg Irbesartan doses, the scientists say.

As a result, they suggest urinary proteome analysis could provide statistically significant results within small testing populations for the potential benefits of intervention with future therapies.

Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

EuCheMS Chemistry Congress

Jul 07 2024 Dublin, Ireland

HPLC 2024

Jul 20 2024 Denver, CO, USA

ICMGP 2024

Jul 21 2024 Cape Town, South Africa

ACS National Meeting - Fall 2024

Aug 18 2024 Denver, CO, USA

JASIS 2024

Sep 04 2024 Chiba, Tokyo, Japan

View all events