Electrophoretic Separations
Protein expression pattern identified for cervical cancer
Jun 23 2011
Cervical cancer is a big killer in the female population, with this type of cancer an excellent model for further investigation in the mechanisms of disease development and progression as it is almost always caused by the Human Papilloma Virus (HPV).
In the study, published in the BMC Systems Biology journal, the team sought to identify the common proteomic profile of six cervical cancer cell lines, both positive and negative for HPV, and which differ from the profile corresponding to the non-tumourgenic cell line, HaCat.
Using quantitative analysis of 2D SDS-PAGE and MALDI-TOF mass spectrometry, the scientists identified a consensus of 66 proteins from the protein extracts of six cervical cancer cell lines.
The team determined that there is a 'central core of cervical cancer' protein expression pattern, with protein 14-3-3zeta identified as a major factor in determining if the cell lives or dies.
Digital Edition
Chromatography Today - Buyers' Guide 2022
October 2023
In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...
View all digital editions
Events
Jul 07 2024 Dublin, Ireland
Jul 20 2024 Denver, CO, USA
Jul 21 2024 Cape Town, South Africa
ACS National Meeting - Fall 2024
Aug 18 2024 Denver, CO, USA
Sep 04 2024 Chiba, Tokyo, Japan