GC, MDGC

The Value of Lean Sigma: Improving GC Processes in Pharmaceutical R&D

Feb 28 2012

Author: Karen Rome on behalf of Unassigned Independent Article

Free to read

This article has been unlocked and is ready to read.

Download

In an increasingly competitive market, today’s science and technology strategies must deliver a superior product to the market in less time and for less cost. Efficient product and process delivery are optimised by encouraging real time analysis; putting the technique into the hands of the customer is essential to this. 

Gas Chromatography-Flame Ionisation Detection (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS) are techniques fundamental to the pharmaceutical R&D industry. These techniques measure the quality of raw materials and intermediates used in the manufacture of active pharmaceutical ingredient (API) and deliver knowledge into the synthetic organic process for effective learning. Raw materials, intermediates and impurities seen in the manufacturing process typically cover a wide range of polarities and are often highly structurally related, (e.g positional isomers). The supporting analytical methods must therefore be highly efficient and selective. 
As a consequence, compound specific methods are typically developed.
Internal data show compound specific methods are struggling to support increased project demand. This article discusses the combination of new lean methodologies with advances in column technologies in order to improve efficiency of the GC process from method development to commercial technology transfer. These improvements have successfully responded to increased project demands in our organisation without requirement for large-scale financial investment. 

Free to read

This article has been unlocked and is ready to read.

Download


Digital Edition

Chromatography Today - Buyers' Guide 2022

October 2023

In This Edition Modern & Practical Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr...

View all digital editions

Events

analytica 2024

Apr 09 2024 Munich, Germany

Korea Lab 2024

Apr 23 2024 Kintex, South Korea

Korea Chem 2024

Apr 23 2024 Seoul, South Korea

AOCS Annual Meeting & Expo

Apr 28 2024 Montreal, Quebec, Canada

SETAC Europe

May 05 2024 Seville, Spain

View all events